Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Characterization and evaluation of the leachability of bottom ash from a mobile emergency incinerator of COVID-19 medical waste: A case study in Huoshenshan Hospital, Wuhan, ChinaCOVID-19 의료 폐기물 이동식 비상 소각로에서 바닥재의 침출성 특성 및 평가: 중국 우한 Huoshenshan 병원 사례 연구Article Published on 2022-02-012022-09-11 Journal: Journal of environmental management [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition changed characterization chemical property chlorinated conducted consultation COVID-19 COVID-19 pandemic COVID-19 virus evaluate Heavy metals Huoshenshan Hospital Incineration indicated Infectious disease Infectious diseases Leachability management Medical waste bottom ash Metals. pandemic physiological saline Polypropylene produced risk secondary transmission Trace element trace elements Treatment was used Wuhan Wuhan, China [DOI] 10.1016/j.jenvman.2021.114161 PMC 바로가기 [Article Type] Article
Nanomaterials as Promising Theranostic Tools in Nanomedicine and Their Applications in Clinical Disease Diagnosis and TreatmentReview Published on 2021-12-102022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] Aneurysm application Atherosclerosis bottleneck cardiovascular diseases carrier cause Characteristics chemical property clinical Complete COVID-19 death Diagnosis disadvantage disease Diseases drugs Effectiveness FIVE genomic sequencing Health helping imaging diagnosis IMPROVE involved molecular mechanism Myocardial infarction Nanomaterial nanomaterials nanomedicine Nanoparticles overcome Pathogenesis pathway physical predict Research second sensitivity significantly Stage therapeutic approach therapeutic effect therapy Transmission Treatment unique variety viral infection viral pathogenesis [DOI] 10.3390/nano11123346 PMC 바로가기 [Article Type] Review
Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders인간 건강 및 장애에 대한 치료학적 적용을 위한 압타머의 식별 및 엔지니어링Review Published on 2021-09-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 진단, 치료제, [키워드] antibody application approach aptamer aptasensor Biomarker Care chemical properties chemical property Chemistry clearance Cost effectiveness COVID-19 demonstrated diagnostic different disease different diseases digestion disease pathology Engineering Food industry Frame fungal infections Health heterogeneity Human identification Immunotherapy In-vitro initial Lateral flow assay (LFA) ligands maintain Modification molecular Molecular biology molecular imaging Nuclease oligonucleotide physical protein level proteomics renal renal clearance sensitivity Sensitivity and specificity sensor sequence shelf life Single Cell single cell proteomics stem cell stem cells systematic evolution of ligands by exponential enrichment (SELEX) theranostic therapeutic Treatment Variation while [DOI] 10.3390/ijms22189661 PMC 바로가기 [Article Type] Review
Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 proteaseTheobroma cacao L. 화합물: 주요 SARS-CoV-2 프로테아제 억제제로서의 이론적 연구 및 분자 모델링Article Published on 2021-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료제, [키워드] acute respiratory syndrome alanyl antioxidant binding binding efficiency Bioflavonoids carbonyl cause chemical property Cocoa bean complex Compound coronavirus COVID-19 DFT enzyme evaluated free energy Free energy calculation Free energy calculations high affinity in silico in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 Ligand molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations naringin performed presenting protease Quantum mechanics rutin SARS-CoV-2 SARS-CoV-2 protease Severe acute respiratory syndrome starting point Structural analysis Theobroma cacao Theobroma cacao. [DOI] 10.1016/j.biopha.2021.111764 PMC 바로가기 [Article Type] Article
Ruthenium Complexes in the Fight against Pathogenic Microorganisms. An Extensive ReviewReview Published on 2021-06-132022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] Activation Antibacterial antibiotic anticancer antimicrobial antimicrobial agent antimicrobial agents antiparasitic Antiviral antiviral activity antiviral drug Bacterial cellular cellular processes chemical property clinical trial complexes Compound COVID-19 develop disadvantage drug candidates drug-resistant effective eukaryotic cell event Extensive involved knowledge Ligand mechanism of action metabolism microorganisms pandemic Population reactive oxygen specy review ROS ruthenium SARS-CoV-2 substrate unique use of antibiotics widespread [DOI] 10.3390/pharmaceutics13060874 PMC 바로가기 [Article Type] Review